Pathophysiology of pain in venous disease

Nicolas DANZIGER Fédération de Neurophysiologie Clinique, Faculté de Médecine Pitié-Salpêtrière, Pitié- Salpêtrière Medical Center, Paris, France SUMMARY Pain is the chief complaint that leads to the diagnosis of venous disease and it has a significant impact on patients’ quality of life. But for the clinician as well as the researcher, pain in venous disease is difficult to assess, both because of its multifaceted nature and due to the absence of a close relationship between pain as a symptom and the severity of venous disease. Current hypotheses on the mechanisms of pain in venous disease emphasize a local inflammatory origin. However,…

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Interaction between ageing, inflammation process, and the occurence of varicose veins

Julia Buján Gemma Pascual Juan M. Bellón Department of Medical Specialities Department of Surgery Faculty of Medicine, University of Alcalá Alcalá de Henares Madrid, Spain SUMMARY Failure of the vein wall continues to be a subject of intense research, the aim of which is to establish a cause that will allow us to prevent or at least slow down this undesirable process. We have investigated the role played by inflammatory cells, especially leukocytes, in the etiology of varicose veins. We hypothesize that venous insufficiency could result from the interaction between two processes: tissue aging and abnormalities in the leukocyte/endothelial cell…

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