Effectiveness of micronized purified flavonoid fraction–based conservative treatment in chronic venous edema

Vadim Yu BOGACHEV, MD, PhD On behalf of the VAP-PRO-C3 study investigators group. Department of Faculty Surgery No. 2, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia Abstract Aim: This study assessed the effectiveness of micronized purified flavonoid fraction (MPFF)-based conservative treatment in patients with chronic venous edema (CVE) as part of an observational program that evaluated the management of patients with CVE caused by the primary forms of chronic venous disease (CVD) in real clinical practice. Materials and methods. The VAP-C3 (Vein Act Prolonged-C3; NCT03722836) prospective, single-arm, observational study was conducted in Russia in adult outpatients with CVD…

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2020 Update to classification of chronic venous disorders

Fedor LURIE, MD, PhD Jobst Vascular Institute and the Division of Vascular Surgery at the University of Michigan, Ann Arbor, Michigan, USA. Abstract In 2017, the American Venous Forum (AVF) created a task force to determine if the CEAP classification needed a revision. An extensive literature review led the task force to conclude that there was sufficient evidence to update it to align with the newest knowledge of chronic venous disorder (CVD) and to clarify terminology. Using the modified Delphi methodology, the AVF task force concluded its 2-year project by publishing the CEAP 2020 update, which also became a reporting…

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Use of air plethysmography and ambulatory venous pressure measurement in chronic venous disease

Seshadri RAJU, MD, FACS The RANE Center, St Dominic’s Memorial Hospital, Jackson, Mississippi, USA. Abstract Air plethysmography (APG) and ambulatory venous pressure (AMVP) measurement are functional tests used in chronic venous disease (CVD). We review our experience with these tests in 8456 CVD limbs seen over a 20-year period. The venous filling index (VFI90) parameter in the APG test shows progressive significant worsening as reflux and disease severity increase. Venous volume (VV) also increases—a sign of venous pooling—with reflux and disease progression. This is compensated to a large extent by a parallel increase in ejection volume to as much as…

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Diagnosis and treatment of situational great saphenous vein reflux in daily medical practice

Yu. T. TSUKANOV, A. Yu. TSUKANOV, Department of Surgery and Urology, Omsk State Medical University, Omsk, Russia Abstract Aim: To analyze the treatments for situational great saphenous vein (GSV) reflux. Methods: Patients with chronic venous disease who were classified as C0s, C0,1s, and C2 (n=294) were analyzed using a day orthostatic load (DOL) test. Situational GSV reflux occurred in 78 patients. The patients classified as C0s and C0,1s (group 1; n=46) and the patients with reflux still present after surgery on varicose tributaries (group 3; n=10) received micronized purified flavonoid fraction (MPFF) 1000 mg daily for 90 days. Patients classified…

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A quality of life tool kit in chronic venous disorders

A quality of life tool kit in chronic venous disorders Robert Launois REES France, 48, rue d’Assas, 75006, Paris, France Abstract Individual preferences are now at the center of the medical decision-making process. Different experimental methods are used to determine preferences. Psychometricians use direct observation of a subject’s reaction in a particular pathological situation: patients are asked to arrange the intensity of the impacts on numerical ordinal scales, but an actual metrical measure is not yet available. Traditionally, economists believe that in a market, only the consumer’s choices enable us to estimate his or her level of satisfaction. In the…

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