Servier – Phlebolymphology

• Reverse foam sclerotherapy of the great saphenous vein and saphenofemoral ligation compared to standard and invagination stripping: A prospective clinical series.Abela R, Liamis A, Prionidis I, Mathai J, Gorton L, Browne T, Panayotopoulos Y.
Eur J Vasc endovasc Surg. 2008:36:485-490.
Table XIII | Article in PubMed

• Does longitudinal or transverseorientation of the ultrasound probeimprove cannulation success in minimallyinvasive venous surgery: A multicentrerandomised controlled trialAherne, Zafar AS, Gourlay D, O'Neil DC, Bashar K, Yap CJQ, Tang TY, Walsh SR.
Phlebology 2020,35,686-92.
Table XXXXXXVII

• Radiofrequency Endovenous Closure FASTversus Laser Ablation for the Treatment of Great Saphenous Reflux: A Multicenter, Single-blinded, Randomized Study (RECOVERY Study).Almeida JI, Kaufman J, Oliver Göckeritz O, Chopra P, Evans M T, Hoheim DF, Makhou RG, Richards T, Wenzel C,Raines JK.
J Vasc Interv. Radiol. 2009;20:752–759.
Table X | Article in PubMed

• Efficacy and safety of sclerotherapy polidocanol foam: a controlled clinical trial.Alos J, Carreno P, Lopez JA, Estadella B, -Prat M, Marinel-lo J.
Eur J Vasc Endovasc Surg. 2006;31:101-107.
Table XXI | Article in PubMed

• Prospective randomized controlled trial : conventional versus powered phlebectomy.Aremu M, Mahendran B, Butcher W, Khan Z, Colgan MP,Moore J et al.
J Vasc Surg. 2004;39:88-94.
Table VI | Article in PubMed

• Impact of copper compression stockings on venous insufficiency and lipodermatosclerosis: A randomised controlled trialArendsen LP, Vig S, Thakar R, Sultan AH
Phlebology. 2019 May;34(4):224-230
Table XXXXII | Article in PubMed

• Traditional versus Endoscopic Saphenous Vein Stripping: A Prospective Randomized Pilot Trial.Assadian A, Wickenhauser G, Hübl W, B. Wiltos B, A. Sami A, Senekowitsch C, G.W. Hagmüller GW.
Eur. J Vasc Endovasc Surg. 2008;36:611-615.
Table XVI | Article in PubMed

• Compression versus No Compression after Endovenous Ablation of the Great Saphenous Vein: A Randomized Controlled Trial.Ayo D, Blumberg SN, Rockman CR, Sadek M, Cayne N, Adelman M, Kabnick L, Maldonado T, Berland T.
Ann Vasc Surg. 2017 Jan;38:72-77
Table XXVIITable XXXIV | Article in PubMed

• Compression Stockings after Endovenous Laser Ablation of the Great Saphenous Vein: A Prospective Randomized Controlled Trial.Bakker NA, Schieven LW, BruinsRMG, van den Berg M Hissink RJ.
Eur. J Vasc Endovasc Surg. 2013;46:588-592.
Table XII | Article in PubMed

• Comparaison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomised controlled trial.Barwell JR, Davies CE, Deacon J, Harvey K, Minor M, Sassano A; Taylor M et al.
Lancet. 2004;363:1854-1859.
Table II | Article in PubMed

• Flush ligation of the saphenofemoral junction versus simple, distal ligation, 10 year, follow-up. The safe study. Angeiologie. Belcaro G, Nicolaides AN, Cesarone NM, De Sanctis MT, Incandela L, Errichi BM et al.
Angeiologie. 2002;54:19-23.
Table XVI

• External femoral vein valvuloplasty with limited anterior plication (LAP) : a 10-year randomized, follow-up study .Belcaro G, Nicolaides AN, Ricci A, Laurora G, Errichi BM, Cesarone MR, De Sanctis MT. Incandela L.
Angiology. 1999;50:531-536.
Table XXXXVI | Article in PubMed

• Endovascular sclerotherapy, surgery and surgery plus sclerotherapy in superficial venous incompetence. A randomized, 10-year follow-up trial-Final results. Belcaro G, Nicolaides AN, Ricci A, Dugall M, Errichi BM, Vasdekis S Christopoulos D.
Angiology. 2000;51:529-534.
Table XIIITable XVI | Article in PubMed

• Foam sclerotherapy, surgery,sclerotherapy and combined treatment for varicose veins. A 10-year, prospective, randomised, controlled trial (VEDICO trial).Belcaro G, Cesarone NM, Di Renzo A, Bandolini R, Coen L, Acerbi G et al.
Angiology. 2003;54:307-315.
Table XIII | Article in PubMed

• Prospective, double-blind, randomized controlled trial comparing electrocoagulation and radiofrequency in the treatment of patients with great saphenous vein insufficiency and lower limb varicose veins.Beteli C, Henrique Rossi F, Lorençao de Almeida B, Mitsuru Izukawa N, Bossolani Onopfre Rossi C, Atique Gabriel S et al.
JVS V&L.2018;6:212-219
Table XXXVI | Article in PubMed

• Comparing endovenous laser ablation, foam sclerotherapy, and conventional surgery for great saphenous varicose veins.Biemans AAM, Kockaert M, Akkersdijk GP, van den Bos RR, de Maeseneer MGR, 240 Cuypers P et al.
J Vasc Surg. 2013;58:727-734.
Table XIV | Article in PubMed

• Randomized Clinical trial of the duration of compression therapy after varicose vein surgery.Biswas S, Clark A, Shield DA.
Eur J Vasc Endovasc Surg. 2007;33:631-637.
Table XXXXXVIII | Article in PubMed

• Ablation of the great saphenous vein withF-care versus Closurefast endovenousradiofrequency therapy: Double-blindedprospective studyBitargil, Kiliç HE
Phlebology 2020,35,561–565
Table XXVII | Article in PubMed

• Ultrasound-Guided Sclerotherapy of the Great Saphenous Vein with 1% vs. 3% Polidocanol Foam: A Multicentre Double-Blind Randomised Trial with 3-Year Follow-Up. Blaise S, Bosson Jl, Diamand JM.
Eur J Vasc Endovasc Surg. 2010;39:779-786.
Table XXII | Article in PubMed

• Late follow-up of a randomized trial of routine duplex imaging before varicose vein surgery.Blomgren L, Johansson G, Emmanuelson L, Dahlberg-Akerman A, Thermaenius P, Berrgqvist D.
Br J Surg. 2011;98:1112–1116.
Table XXXXVIITable XXXXXI | Article in PubMed

• Perioperative administration of micronized purified flavonoid fraction in endovascular treatment of varicose diseaseBogachev V, Boldin BV, Turkin PI
Angiol Sosud Khir. 2019;25(2):88-95
Table XIITable XXVIITable XXXXXV | Article in PubMed

• Benefits of micronized purified flavonoid fraction as adjuvant therapy on inflammatory response after sclerotherapy.Bogachev VY, Boldin BV, Lobanov VN.
Int angiology. 2018;37(1):71-78.
Table XXXVIITable XXXXIII | Article in PubMed

• A randomised trial of different compression dressings following varicose vein surgery.Bond R, Whyman M R, Wlikins D C, Walker A J, Ashley S.
Phlebology. 1999;14:9-11. DOI : 10.1177/026835559901400103
Table XXXXXVIII

• Intra-procedural pain score in a randomised controlled trial comparing mechanochemical ablation to radiofrequency ablation: The Multicentre VenefitTM versus ClariVein® for varicose veins trial.Bootun R, Lane TRA, Dharmarajah B, Lim CS, Najem M, Renton S, Sritharan K, Davies AH.
Phlebology. 2016;31(1):61-65.
Table XXXXXXI | Article in PubMed

• Ultrasound guided foam sclerotherapy combined with sapheno-femoral ligation compared to surgical treatment of varicose veins: early results of a randomised contolled trial.Bountouroglou DG, Azzam M, Pathmarajh M, Young P , Geroulakos G.
Eur J Vasc Endovasc Surg. 2006;31:93-100.
Table XIII | Article in PubMed

• A prospective comparison of a new cyanoacrylate glue and laser ablation for the treatment of venous insufficiency.Bozkurt AK, Yilmaz MF.
Phlebology. 2016;31(1 Suppl):106-113.
Table XXIX | Article in PubMed

• Comparison of Endovenous Laser and Radiofrequency Ablation in Treating Varicose Veins in the Same Patient.Bozoglan O, Mese B, Eroglu E, Erdogan MB, Erdem K, Ekerbicer HC, Yasim A.
Vasc & Endovasc Surg. 2016;50(1):47-51.
Table X | Article in PubMed

• A Randomized Trial Comparing Treatments for Varicose Veins.Brittenden C, Cotton SC, Elders A, Ramsay CR, Norrie J, Burr J et al.
New Engl J Med. 2014.371(13):1218-1227.
Table XIV | Article in PubMed

• Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial.Brittenden J, Cotton SC, Elders A, Tassie E, Scotland G, Ramsay CR, Norrie J, Burr J, Francis J, Wileman S, Campbell B, Bachoo P, Chetter I, Gough M, Earnshaw J, Lees T, Scott J, Baker SA, MacLennan G, Prior M, Bolsover D, Campbell MK.
Health Technol Assess. 2015 Apr;19(27):1-342
Table XIV | Article in PubMed

• Five-Year Outcomes of a Randomized Trial of Treatments for Varicose VeinsBrittenden J , David Cooper, Ph.D., Maria Dimitrova, M.Sc., Graham Scotland, Ph.D., Seonaidh C. Cotton, Ph.D., Andrew Elders, M.Sc., Graeme MacLennan, M.Sc., Craig R. Ramsay, Ph.D., John Norrie, M.Sc., Jennifer M. Burr, M.D., Bruce Campbell, M.B., B.S., Paul Bachoo, M.B
N Engl J Med 2019,381,912-22
Table XIV | Article in PubMed

• Prospective randomized trial comparing conventional (Babcock) stripping with inverting (Pin) stripping of the long saphenous vein.Buttler CM, Scurr JH, Coleridge Smith PD.
Phlebology. 2002;17:59-63. doi: 10.1177/026835550201700204
Table XVI

• Ablation therapy with cyanoacrylate glue and laser for refluxing great saphenous veins - a prospective randomised studyÇalik ES, Arslan Ü, Erkut B
Vasa. 2019 Aug;48(5):405-412
Table XXIX | Article in PubMed

• Standard stripping versus long saphenous vein saving surgery for primary varicose veins : a prospective, randomized study with the patients as their own controls.Campanello M, Hammarsten J, Forsberg S,C,Bernland P et al.
Phlebology. 1996;11:45-49. doi: 10.1177/026835559601100202
Table VTable XXXXXI

• Stripping vs haemodynamic correction (CHIVA): a long term randomised trial.Carandina S, Mari C, De Palma M, et al.
Eur J Vasc Endovasc Surg. 2008;35:230-237.
Table VIITable XXXXXI | Article in PubMed

• Clinical efficacy and safety of a new 1000-mg suspension versus twice-daily 500-mg tablets of MPFF in patients with symptomatic chronic venous disorders: a randomized controlled trialCarpentier P, van BELLEN Bonno, KARETO VA Debora, HANAFIAH Harunarashid et al
International Angiology 2017 October;36(5):402-409
Table XXXXXIX | Article in PubMed

• Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins.Carradice D, Mekako AI, Hatfield J,Chetter IC.
Br J Surg. 2009;96:369-375.
Table XII | Article in PubMed

• Randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins.Carradice D, Mekako AI, Mazari FAK,Samuel N,Hatfield J, Chetter IC.
Br J Surg. 2011;98:501-510.
Table VIII | Article in PubMed

• Clinical and technical poutcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins.Carradice D, Mekako AI, Mazari FAK,Samuel N,Hatfield J, Chetter IC.
Br J Sur. 2011;98:1117-1123.
Table VIII | Article in PubMed

• Great saphenous vein surgery without high ligation of the saphenofemoral junction.Casoni P, Lefebvre-Villardebo M, Villa F, Corona P.
J Vasc Surg 2013;58:173-178.
Table XVITable XXXXXI | Article in PubMed

• Compression with 23 mmHg or 35 mmHg stockings after saphenous catheter foam sclerotherapy and phlebectomy of varicose veins: A randomized controlled studyCavezzi A, Mosti G, Colucci R, Quinzi V, Bastiani L, Urso SU
Phlebology. 2019 Mar;34(2):98-106
Table XXXXIV | Article in PubMed

• Blocking the saphenofemoral junction during ultrasound-guided foam sclerotherapy-- assessment of a presumed safety-measure procedure.Ceulen RP, Jagtman EA, Sommer A, Teule GJ, Schurink GW, Kemerink GJ
Eur J Vasc Endovasc Surg. 2010 Dec;40(6):772-6
Table XXXXVIII | Article in PubMed

• Outcomes and side effects of duplex-guided sclerotherapy in the treatment of great saphenous veins with 1% versus 3% polidocanol foam: results of a randomized controlled trial with1-Year follow-up.Ceulen RPM, Bullens-Goessens YIJM, Pi-Van De Venne SJA, Nelemans PJ, Veraart JCJM, Sommer A.
Dermatol Surg. 2007;33:276-281.
Table XXII | Article in PubMed

• Randomized clinical trial comparing multiple stab incision phlebectomy and transilluminated powered phlebectomy for varicose veins.Chetter I C, Mylankal, K J, Hughes H, Fitridge R.
Br J Surg. 2006;93:169-174.
Table VI | Article in PubMed

• Prospective randomized trial comparing endovenous laser ablation and surgery for treatment of primary great saphenous varicose veins with a 2-year follow-up.Christenson JT, Gueddi S, Gemayel G, Bounameaux H.
J Vasc Surg. 2010;52:1234-1241.
Table VIII | Article in PubMed

• Wound infection following high saphenous ligation: a trial comparing two skin closure techniques:subcuticular polyglycolic acid and interrupted monofilament nylon mattress sutures.Corder AP, Schache DJ, Farquharson SM, Tristram S.
JR Coll Surg Ed. 1991;36(2):100-102.
Table XVI | Article in PubMed

• Randomized Clinical trial comparing endovenous laser ablation with surgery for the treatment of primary great saphenous veins.Darwood RJ, Theivacumar N, Dellagrammaticas D, Mayor AL, Gough MJ.
Br J Surg. 2008; 95: 294-301.
Table VIII | Article in PubMed

• Comparison of endovenous treatment with an 810 nm laser versus conventional stripping of the great saphenous vein in patients with primary varicose veins.de Medeiros CA, Luccas GC.
Dermatol Surg. 2005;31:1685-1694.
Table VIII | Article in PubMed

• Ambulatory phlebectomy versus compression sclerotherapy: results of a randomized controlled trial.De Roos KP, Nieman FHM, Neumann M.
Dermatol Surg. 2003;29:221-226.
Table XIII | Article in PubMed

• Catheter-directed Foam Sclerotherapy of Great Saphenous Veins in Combination with Pre-treatment Reduction of the Diameter Employing the Principals of Perivenous Tumescent Local Anesthesia.Devereux N, Recke AL, Westerman L, Recke A, Kahle B.
EJEVS. 2014;47:187-195.
Table XXXIX | Article in PubMed

• Is there a risk for lymphatic complications after endovenous laser treatment versus cryostripping of the great saphenous vein ? A prospective study.Disselhoff BC, der Kinderen DJ, Moll FL.
Phlebology. 2008;23:10-14.
Table XVIII | Article in PubMed

• Randomized clinical trial comparing endovenous laser with cryostripping for great saphenous varicose veins.Disselhoff BC, der Kinderen DJ, Kelder JC, Moll FL.
Br J Surg. 2008; 95:1232-1238.
Table XVIII | Article in PubMed

• Randomized clinical trial comparing endovenous laser ablation of the great saphenous vein with and without ligation of the saphenofemoral junction: 2-year results.Disselhoff BC, der Kinderen DJ, Kelder JC, Moll FL.
Eur J Vasc Endovasc Surg. 2008;36:713-718.
Table XII | Article in PubMed

• Randomized comparison of Costs and Cost-effectiveness of cryostripping and Endovenous Laser ablation for Varicose veins: 2 –Year results.Disselhoff BC, Buskens E, Kelder JC, der Kinderen DJ, Moll FL
Eur J Vasc Endovasc Surg. 2009;37:357-363. 19111485
Table XVIII | Article in PubMed

• Five-year results of a randomised clinical trial of endovenous laser ablation of the great saphenous vein with and without ligation of the saphenofemoral junction.Disselhoff BC, der Kinderen DJ, Kelder JC, Moll FL.
Eur J Vasc Endovasc Surg. 2011;41;685-690.
Table XIITable XXXXXVI | Article in PubMed

• Five-year results of a randomized clinical trial comparing endovenous laser ablation with cryostripping or great saphenous varicose veins.Disselhoff BC, der Kinderen DJ, Kelder JC, Moll FL.
Br J Surg. 2011;98:1107-1111.
Table XVIII | Article in PubMed

• Comparison of 980 nm Laser and Bare-tip fibre with1470 nm Laser and radial Fibre in the treatment of great Saphenous vein varicosities: A prospective randomized controlled trial.Doganci S, Demirkilic U.
Eur J Vasc Endovasc Surg. 2010;40:254-259.
Table XII | Article in PubMed

• Catheter-directed foam sclerotherapywith tumescence of the great saphenousvein versus ultrasound-guided foamsclerotherapy: A randomizedcontrolled trialdos Santos JB, Junior WC, Porta RMP, Puggina J, da Silva DFT, Puech-Leao P, de Luccia N, da Silva ES
Phlebology2020, Vol. 35(2) 84–91
Table XXXIX

• Comparing cold and warm tumescent anesthesia for pain perception during and after the endovenous ablation procedure with 1470nm diode laser.Dumantepe M, Uyar I.
Phlebology. 2015;30:45-51.
Table XII | Article in PubMed

• Subfascial ligation at three different levels versus partial exeresis of the incompetent short saphenous vein: A randomized clinical trial.Dumas BE, Spronk S, Boelhouwer RU, den Hoed PT.
J Vasc Nur. 2007;25:12-18
Table XVI | Article in PubMed

• A prospective randomised trial of PIN versus Conventional stripping in varicose vein surgery.Durkin MT, Turton EPL, Scott DJA, Berridge DC.
R Coll Surg Engl. 1999; 81: 171–174.
Table XVI | Article in PubMed

• Long Saphenous Vein Stripping and Quality of life – a randomized trial.Durkin MT, Turton EPL, Wijesinghe LD, Scott DJA, Berridge DC.
Eur J Vasc Endovasc Surg. 2001;21:545-549.
Table XVI | Article in PubMed

• Stripping the long saphenous vein reduces the rate of reoperation for recurrent varicose veins. Five-year results of a randomized trial. Dwerryhouse S, Davies B, Harradine K, Earnshaw JJ.
J Vasc Surg. 1999;29:589-592.
Table IVTable XXXXXI | Article in PubMed

• Haemostatic activation and Inflammatory response after three methods of treatment of great saphenous vein incompetence.Dzieciuchowicz L, Espinosa G, Páramo JA.
Phlebology. 2014;29:154–163.
Table XI | Article in PubMed

• Sclerotherapy or surgery as treatment for varicose veins: A prospective randomized study.Einarsson E, Eklöf B, Neglén P.
Phlebology. 1993;8:22-26. doi: 10.1177/026835559300800106
Table XIIITable XXXXXI

• Clinical outcomes and quality of life 5 years after a randomized trial of concomitant or sequential phlebectomy following endovenous laser ablation for varicose veins.El-Sheika J, Nandrah S, Carradice D, Wallace T, Samuel N, Smith GE et al.
Br J Surg. 2014;101:1093-1097.
Table XII | Article in PubMed

• Role of compression stockings after endovenous laser therapy for primary varicosisElderman JH, Krasznai AG, Voogd AC, Hulsewé KW, Sikkink CJ
J Vasc Surg Venous Lymphat Disord. 2014 Jul;2(3):289-96
Table XII | Article in PubMed

• Great saphenous vein radiofrequency ablation versus standard stripping in the management of primary varicose veins- a randomized clinical trial.Elkaffas KH, Elkashef O, Elbaz W.
Angiology. 2010;62:49-54.
Table IX | Article in PubMed

• Cost-effectiveness analysis of a randomized clinical trial ofearlyversusdeferred endovenous ablation of superficial venousreflux in patients with venous ulcerationEpstein DM, Gohel MS, Heatley F, Liu X, Bradbury A, Bulbulia R, Cullum N, Nyamekye I, Poskitt KR, Renton S, Warwick J, Davies AH
BJS2019;106: 555–562
Table XXXX | Article in PubMed

• A Randomised Clinical Trial Comparing N-Butyl Cyanoacrylate, Radiofrequency Ablation and Endovenous Laser Ablation for the Treatment of Superficial Venous Incompetence: Two Year Follow up results.Eroglu E, Yasim A.
EJEVS. 2018;56:553-560.
Table XXXII | Article in PubMed

• Results of surgical treatment compared with Ultrasound- guided foam sclerotherapy in patients with varicose veins : a prospective randomised trial.Figueiredo M, Araujo Q, Barros Jr N, Miranda Jr F.
Eur J Vasc Endovasc Surg. 2009;38:758-763.
Table XIII | Article in PubMed

• Endovenous laser ablation with and without high ligation compared with high ligation and stripping in the treatment of great saphenous varicose veins: initial results of a multicentre randomized controlled trial.Flessenkämper I, Hartmann M, Stenger D, Roll S.
Phlebology. 2013;28:16-23.
Table VIIITable XII | Article in PubMed

• Endovenous laser ablation with and without high ligation compared with high ligation and stripping for treatment of great saphenous varicose veins: Results of a multicentre randomised controlled trial with up to 6 years follow-up.Flessenkämper I, Hartmann M, Hartmann K, Stenger D, Roll S.
Phlebology. 2016;31(1):23,33.
Table VIIITable XIITable XXXXXI | Article in PubMed

• Reduction of neoreflux after correctly performed ligation of the Saphenous junction. A randomized trial. Frings N, Nelle A, Tran Ph, Fischer R, Krug W.
Eur J Vasc Endovasc Surg. 2004;28:246-252.
Table XVITable XXXXXI | Article in PubMed

• A randomized, controlled trial of endovenous thermal ablation using the 810-nm wavelength laser and the ClosurePLUS radiofrequency ablation methods for superficial venous insufficiency of the great saphenous vein.Gale SS. Lee JN, Walsh ME, Wojnarowski DL, Comerota AJ.
J Vasc Surg. 2010;52: 645-650.
Table X | Article in PubMed

• Five-year follow-up of a randomized, controlled trial comparing saphenofemoral ligation and stripping of the great saphenous vein with endovenous laser ablation (980 nm) using local tumescent anesthesia.Gauw SA, Lawson JA, van Vlijmen-van Keulen CJ, Pronk P, Gaastra MT, Mooij MC.
J Vasc Surg. 2016;63(2):420-428.
Table VIII | Article in PubMed

• Reoperation for recurrent saphenofemoral incompetence: a prospective randomized trial using a reflected flap of pectineus fascia.Gibbs PJ, Foy DMA, Darke SG.
Eur J Vasc Endovasc Surg. 1999;18:494-498.
Table XVITable XXXXXI | Article in PubMed

• A multicenter, randomized, placebo-controlled study to evaluate the efficacy and safety of Varithena® (polidocanol endovenous microfoam 1%) for symptomatic, visible varicose veins with saphenofemoral junction incompetence.Gibson K, Kabnick L; Varithena® 013 Investigator Group.
Phlebology. 2017 Apr;32(3):185-193.
Table XX | Article in PubMed

• Twenty-four month results from a randomized trial of cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins. Gibson K, Morrison N, Kolluri R, Vasquez M, Weiss R, Cher D, Madsen M, Jones A.
J Vasc Surg Venous and Lym Dis 2018;6:607-613.
Table XXX | Article in PubMed

• Clinical superiority of an innovative two-component compression system versus four-component compression system in treatment of active venous leg ulcers: A randomized trial Gillet JL, Guex JJ, Allaert FA, Avouac B, Leger P, Blaise S, Marchand A, Maillard H, Simon M, Amor CB, Pasqualini M
Phlebology. 2019 Oct;34(9):611-620
Table XXXXXIII | Article in PubMed

• A Randomized Trial of Early Endovenous Ablation in Venous Ulceration.Gohel MS, Heatley F, Liu X, Bradburry A, Bulbubia R, Cullum M et al.
N Engl J Med. 2018;378:2105-2114.
Table XXXX

• Randomized clinical trial of compression plus surgery versus compression alone in chronic venous ulceration (ESCHAR study)- haemodynamic and anatomical changes.Gohel MS, Barwell JR, Earnshaw JJ, Heather BP, Mitchell DC, Whyman MR, Poskitt KR.
Br J Surg. 2005;92:291-297.
Table II | Article in PubMed

• Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR). Randomised controlled trial. Gohel MS, Barwell JR, Taylor M, Chant T, Foy C , Earnshaw JJ Heather BP, Mitchell DC, Whyman MR, Poskitt KR.
Br J Surg. 2007;335(7610):83. 17545185
Table II | Article in PubMed

• Treatment of varicose and telangiectatic leg veins: double-blind prospective comparative trial between aethoxyskerol and sotradecolGoldman MP,
Dermatol Surg. 2002 Jan;28(1):52-5.
Table XXXXIII | Article in PubMed

• Laser and Radiofrequency ablation Study): a randomized Study comparing Radiofrequency Ablation and Endovenous Laser Ablation ( 810 nm).Goode SD, Chowdurry A, Crockett M, Beech A, Simpson R, Richards, Braithwaite BD.
Eur J Vasc Endovasc Surg. 2010;40:246-253.
Table X | Article in PubMed

• Randomized clinical trial of varicose vein surgery with compression versus compression alone for the treatment of venous ulceration.Guest M, Smith JJ, Tripuraneni G, Howard A, Madden P, Greenhalgh RM, Davies AH.
Phlebology. 2003;18:130-136. doi:10.1258/026835503322381333
Table II

• Less Painful Tumescent Solution for Patients Undergoing Endovenous Laser Ablation of the Saphenous Vein.Gunes T, Altin F, Kutas B, Aydin S, Erkoc K, Eygi B, Alur I, Ozdemir F
Ann Vasc Surg. 2015; 29(6):1123-1127
Table XII | Article in PubMed

• Recurrence rate by neovascularization following a modification of long saphenous vein operation in the groin: a prospective randomized duplex-ultrasound controlled study. [in German]Haas E, Burkhardt T, Maile.
Phlebologie. 2005;34:101-4.
Table XVITable XXXXXI

• Randomized clinical trial of endovenous laser ablationversusdirect and indirect radiofrequency ablation for the treatment ofgreat saphenous varicose veinsHamann SAS, Timmer-de Mik L, Fritschy WM, Kuiters GRR, Nijsten TEC, van den Bos RR
BJS2019;106: 998–1004
Table XTable XXVII | Article in PubMed

• [Etude 3/1. Mousse de polidocanol 3% versus 1% dans la grande veine saphène: premiers résultats.]Hamel-Desnos C, Allaert FA, Benigni J-P, Boitelle G, Chleir F, Ouvry P,et al.
Phlébologie. 2005;58:165-173. In French. ISSN 0031-8280 CODEN PHLBA2
Table XXII

• Evaluation of the efficacy of polidocanol in the form of foam compared with liquid form in sclerotherapy of the greater saphenous vein: initial results.Hamel-Desnos C, Desnos P, Wollmann J, Ouvry P, Mako S, Allaert FA.
Dermatol Surg. 2003;29:1170–1175.
Table XXI | Article in PubMed

• Comparison of 1% and 3% polidocanol foam in ultrasound guided sclerotherapy of the great saphenous vein: a randomized, double-blind trial with 2 year-follow-up. The 3/1 study. Hamel-Desnos C, Ouvry P, Benigni JP, Boitelle G, Schadeck M, Desnos P et al.
Eur J Vasc Endovasc Surg. 2007;34:723-729.
Table XXII | Article in PubMed

• Foam sclerotherapy of the saphenous veins: randomized controlled trial with or without compression.Hamel-Desnos C, Guias B.J., Desnos P.R., Mesgard A.
Eur J Vasc Endovasc Surg. 2010;39:500-507.
Table XXIII | Article in PubMed

• In vivo biological effects of foam sclerotherapy.Hamel-Desnos C, Desnos P.R., Ferre B, Le Querec A.
Eur J Vasc Endovasc Surg. 2011;42:238-245.
Table XXIII | Article in PubMed

• Sclerotherapy of varicose veins in patients with documented thrombophilia: a prospective controlled randomized study of 105 cases.Hamel-Desnos CM, Gillet JL, Desnos PR , Allaert PA.
Phlebology. 2009;24:176-182.
Table XXV | Article in PubMed

• Long saphenous vein saving surgery for varicose vein. A Long term follow-up. Hammarsten J, Pederson P, Cederlund C-G, Campanello M.
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• Long Saphenous vein saving surgery for varicose vein.Hammarsten J, Campanello M, Pedusen P.
Eur J Vasc Surg. 1993;7:763-764.
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• A prospective randomised controlled trial of VNUS Closure versus surgery for the treatment of recurrent long saphenous varicose veins.Hinchliffe RJ, Uhbi J, Beech A, EllisonJ, Braithwaite.
Eur J Vasc Endovasc Surg. 2006;31:212-218.
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• Comparison of 1470 nm Laser and Radial 2ring Fiber with 980 nm Laser and Bare-Tip Fiber in Endovenous Laser Ablation of Saphenous Varicose Veins: A Multicenter, Prospective, Randomized, Non-Blind Study.Hirokawa M, Ogawa T, Sugawara H, Shokoku S, Sato S.
Ann Vasc Dis. 2015;8(4):282-289.
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• The effect of nitroglycerin ointment on great saphenous vein targeted venous access size diameter with endovenous laser treatment.Hogue RS, Schul MW, Dando CF, Erdman BE .
Phlebology. 2008;23:222-226.
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• Two-year results of a multicenter randomized controlledtrial comparing Mechanochemical endovenous Ablationto RADiOfrequeNcy Ablation in the treatment of primarygreat saphenous vein incompetence (MARADONA trial)Holewijn S, Van Eekeren RRJP, Vahl A, de Vries JPPM, Reijnen MMPJ
J Vasc Surg Venous Lymphat Disord. 2019 May;7(3):364-374
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• Incidence of lesions of the saphenous nerve after partial or complete stripping of the long saphenous vein.Holme JB, Skajaa K, Holme K.
Acta Chir Scand. 1990;156:145-148.
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• To Wear or not to Wear Compression Stockings after Varicose Vein Stripping: A Randomised Controlled Trial.Houtermans-Auckel JP, van Rossum E, Teijink JAW, Dahlmans AAHR , Eussen EFB Nicolaï SPA, Welten R J.Th.J.
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• Comparative study in leg telangiectasias treatmentwith Nd:YAG laser and sclerotherapyIanosi G, Ianosi S, Calbureanu-Popescu MX, Tutunaru C, Calina D, Neagoe D
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• Neovascularisation is the principal cause of varicose vein recurrence: results of a randomised trial of stripping the long saphenous vein.Jones L, Braithwaite BD, Selwyn D, Cooke S, Earnshaw JJ.
Eur J Vasc Endovasc Surg. 1996;12:442-445.
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• A multi-centre, prospective, randomisedcontrolled feasibility study of plantarresistance exercise therapy for venous legulcers – Results of the PREVUE studyJonker L, Todhunter J, Schutter J, Halliday C, Fisher S
Phlebology2020, Vol. 35(4) 237–246
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• Outcome of different endovenous laser wavelengths for great saphenous vein ablation.Kabnick LS,
J Vasc Surg. 2006;43:88-93.
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• Efficacy of sclerotherapy in varicose veins. A prospective, blinded, placebo-controlled study. Kahle B, Leng K.
Dermatol Surg. 2004;30:723-728.
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• Long Term Results of a Randomized Controlled Trial on Ultrasound Guided Foam Sclerotherapy Combined with Sapheno-femoral Ligation vs Standard Surgery for Varicose Veins.Kalodiki E, Lattimer C R, Azzam M, Shawish E, Bountouroglou D G, Geroulakos G.
J Vasc Surg. 2012;55:451-457.
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• High ligation combined with stripping and endovenous laser ablation of the great saphenous vein: Early results of a randomized controlled study.Kalteis M, Berger I, Messie-Werndl S, Pistrich R, Schimetta W, Pölz W, Hieller F.
J Vasc Surg. 2008;47:822-829.
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• Five-Year Results of a Randomized Controlled Trial Comparing High Ligation Combined With Endovenous Laser Ablation and Stripping of the Great Saphenous Vein.Kalteis M, Adelsgruber P, Messie-Werndl S, Gangl O, Berger I.
Dermatol Surg. 2015;41(5):579-586.
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• Single-blind, randomized study comparing chromated glycerin, polidocanol solution, and polidocanol foam for treatment of telangiectatic leg veinsKern P, Ramelet AA, Wutschert R, Bounameaux H, Hayoz D.
Dermatol Surg. 2004 Mar;30(3):367-72
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• Compression after sclerotherapy for telangiectasias and reticular leg veins: a randomized controlled studyKern P, Ramelet AA, Wütschert R, Hayoz D.
J Vasc Surg. 2007 Jun;45(6):1212-6
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• A double-blind, randomized study comparing pure chromated glycerin with chromated glycerin with 1% lidocaine and epinephrine for sclerotherapy of telangiectasias and reticular veinsKern P, Ramelet AA, Wutschert R, Mazzolai L.
Dermatol Surg. 2011 Nov;37(11):1590-4
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• Randomized clinical trial of the effect of adding subfascial endoscopic perforator surgery to standard great saphenous vein stripping.Kianifard B, Holdstock J, Allen C, Smith C, Price B, Whiteley MS.
Br J Surg. 2007;94:1075-1080.
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• A randomized trial of cryostripping versus conventional stripping of the great saphenous vein.Klem TMAL, Schnater JM, Schütte PR, Hop W, van der Ham AC, Wittens CHA.
J Vasc Surg. 2009;49:403-409.
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• Roll-in phase analysis of clinical study of cyanoacrylate closure for incompetent great saphenous veins.Kolluri R, Gibson K, Cher D, Madsen M, Weiss R, Morrison N.
J Vasc Surg & Venous Lym Dis. 2016;4(4):407-415.
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• A randomised controlled trial comparing compression therapy after radiofrequency ablation for primary great saphenous vein incompetence.Krasznai AG, Sigterman TA, Troquay S, Houtermans-Auckel JP, Snoeijs M, Rensma HG, Sikkink C, Bouwman LH.
Phlebology. 2016;31(2):118-124.
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• A randomised controlled trial comparing compression therapy after stripping for primary great saphenous vein incompetence.Krasznai AG, Sigterman TA, Houtermans-Auckel JP, Eussen E, Snoeijs M, Sikkink KJJ, de Boer EM, Wittens CH, Bouwman LH
Phlebology. 2019 Dec;34(10):669-674
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• A study to compare outcomes of Sodium tetra-decyl sulphate and Polidocanol in the treatment of varicosities due to incompetent tributaries of superficial vein of leg: a randomized controlled trialKushawa JK, Anand A, Sonkar AA, Gupta R
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Table VI

• Clarivein® mechano-chemical ablation an interim analysis of a randomized controlled trial dose-finding study.Lam YL, Toonder IM, Wittens CH.
Phlebology. 2016;31(3):170-176.
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• Eight-year follow-up of a randomized clinical trial comparingultrasound-guided foam sclerotherapy with surgical strippingof the great saphenous veinLam YL, J.A.Lawson, I. M. Toonder,N.H.Shadid, A.Sommer, M. Veenstra,A. M. J. van der Kleij, R. P. Ceulen, E. de Haan, F. Ibrahim, T. van Dooren, F.H.Nieman, C.H.A.Wittens
BJS 2018;105: 692–698
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• A multi-centre randomised controlled trial comparing radiofrequency and mechanical occlusion chemically assisted ablation of varicose veins - Final results of the Venefit versus Clarivein for varicose veins trial.Lane T, Bootun R, Dharmarajah B, Lim CS, Najem M, Renton S, Sritharan K, Davies AH.
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• Ambulatory varicosity avulsion later or synchronized (AVULS). A randomized clinical trial. Lane TRA, Kelleher D, Sheperd AC,Franklin IJ, Davies AU.
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• Validation of a New Duplex Derived Haemodynamic Effectiveness Score, the Saphenous Treatment Score, in Quantifying Varicose Vein Treatments.Lattimer C R, Kalodiki E Azzam M , Geroulakos G.
Eur J Vasc Endovasc Surg. 2012;43:348-354.
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• Cost and Effectiveness of Laser with Phlebectomies Compared with Foam Sclerotherapy in Superficial Venous Insufficiency. Early Results of a Randomised Controlled Trial. Lattimer C R, Azzam M , Kalodiki E Shawish E Geroulakos G.
Eur J Vasc Endovasc Surg. 2012;43:594-600.
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• Interim results on abolishing reflux alongside a randomized clinical trial on laser ablation with phlebectomies versus foam sclerotherapy.Lattimer C R, Kalodiki E, Azzam M, Makris GC, Somiayajalu S,Geroulakos G.
Int Angiol. 2013;22(4):393-403.
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• Comparison of endovenous ablation techniques, foam sclerotherapy and surgical stripping for great saphenous varicose veins. Extended 5-year follow-up of a RCT.Lawaetz M, Serup J, Lawaetz B, Bjoern L, Blemings A, Eklof B, Rasmussen L.
Int Angiol. 2017 Jun;36(3):281-288.
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• Comparative trial between sodium tetradecyl sulfate and glycerin in the treatment of telangiectatic leg veinsLeach BC, Goldman MP
Dermatol Surg. 2003 Jun;29(6):612-4
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• Ultrasound-guided foam sclerotherapy of the great saphenous vein with-saphenofemoral junction ligation compared to standard stripping: a prospective clinical study.Liu X, Jia X, Guo W, Xiong J, Zhang H, Liu M, Du X, Zhang M.
Int Angiol. 2011;30:321-326.
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• Randomized clinical trial comparing bipolar coagulation and standard great saphenous stripping for symptomatic varicose veins.Lorenz D, Gabel W, Retenbacher M, Weissenhode W, Minzlall M, Stengel D.
Br J Surg. 2007;94:434-440.
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• Effects of eccentric compression by a crossed-tape technique after endovenous laser ablation of the great saphenous vein: a randomized study.Lugli M, Cogo A, Guerzoni S, Petti A, Maleti O.
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• Prospective randomized study of endovenous radiofrequency obliteration(Closure procedure) versus ligation and stripping in a selected patient population (EVOLVES Study).Lurie F, Creton D, Eklof B, Kabnick LS, Kistner RL, Pichot O et al.
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• Prospective randomized study of endovenous radiofrequency obliteration (Closure) versus ligation and vein stripping (EVOLVeS) Two-year follow-up.Lurie F, Creton D, Eklof B, Kabnick LS, Kistner RL, Pichot O, Sessa C, Schuller-Petrovic S.
Eur J Vasc Endovasc Surg. 2005;29:67-73.
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• Does surgical correction of the superficial femoral vein valve change the course of varicose disease.Makarova NP, Lurie F, Hmelniker SM.
J Vasc Surg. 2001:33:361-368.
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• Multicenter randomized trial comparing compression with elastic stocking versus bandage after surgery for varicose vein.Mariani F, Marone EM,Gasbarro V, Buccalosi M, Spelta S, Amsler F et al.
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• Economic benefit of a novel dual-mode ambulatory compression device for treatment of chronic venous leg ulcers in a randomized clinical trialMarston WA, Kirsner RS, Tallis A, Hanft JR, Walters J, Farber A; ACTitouch Investigators.
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• Sclerotherapy for Leg Telangiectasia—A Blinded Comparative Trial of Polidocanol and Hypertonic SalineMc Coy S, Evans A, Nicola Spurrier N
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• Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery.Mekako AI, Chetter IC, Coughlin PA, Hatfield J, McCollumPT.
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• Endovenous laser ablation of the great saphenous vein comparing 1920-nm and 1470-nm diode laser.Mendes-Pinto D, Bastianetto P, Cavalcanti Braga Lyra L, Kikuchi R, Kabnick L.
Intern Angiology. 2016;35(6):599-604.
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• Conventional stripping versus cryostripping : a prospective randomised trial to compare improvement in quality of life and complications.Menyhei G, Gyevnar Z, Arato E, Kelemen O, Kollar L.
Eur J Vasc Endovasc Surg. 2008;35:218-223.
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• Randomized clinical trial comparing surgery with conservative treatment for uncomplicated varicose veins.Michaels JA, Brazier JE, Campbell WB, MacIntyre JB, Palfreyman SJ, Ratcliffe J.
Br J Surg. 2006;93:175-181.
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• Randomised clinical trial, observational study and assessment of cost-effectiveness of the treatment of varicose veins (REACTIV trial).Michaels JA, Campbell WB, Brazier JE, et al.
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• A randomized trial of class 2 and class 3 elastic compression in the prevention of recurrence of venous ulcerationMilic DJ, Zivic SS, Bogdanovic DC, Golubovic MD, Lazarevic MV, Lazarevic KK
J Vasc Surg Venous Lymphat Disord. 2018 Nov;6(6):717-723
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• 1064 nm Nd:YAG long pulse laserafter polidocanol microfoam injectiondramatically improves the result ofleg vein treatment: A randomizedcontrolled trial on 517 legs witha three-year follow-upMoreno-Moraga, Smarandache A, Pascu ML, Royo J, Trelles MA
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• Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose).Morrison M, Gibson K, McEnroe S, Goldman M, King T, Weiss R et al.
J Vasc Surg. 2015,61:985-994.
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• Five-year extension study of patients from a randomizedclinical trial (VeClose) comparing cyanoacrylate closureversus radiofrequency ablation for the treatment ofincompetent great saphenous veinsMorrison N, Gibson K, Vasquez M, Weiss R, Jones A
JVS V&L.2020;8:978-89
Table XXXTable XXXXXI

• VeClose trial 12-month outcomes of cyanoacrylate closure versus radiofrequency ablation for incompetent great saphenous veins.Morrison N, Gibson K, Vasquez M, Weiss R, Cher D, Madsen M, Jones A.
J Vasc Surg Venous Lymphat Disord. 2017 May;5(3):321-330.
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• Comparison of cyanoacrylateclosure and radiofrequency ablationfor the treatment of incompetentgreat saphenous veins: 36-Monthoutcomes of the VeClose randomizedcontrolled trialMorrison N, Kolluri R, Vasquez M, Madsen M, Jones A, Gibson K
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• Adjustable compression wrap devices arecheaper and more effective than inelasticbandages for venous leg ulcer healing.A Multicentric Italian RandomizedClinical ExperienceMosti G, Mancini S, Bruni S, Serantoni S, Gazzabin L, Bucalossi M, Polignano R, Mariani F, Luca B, Partsch H
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• A Randomized Clinical Trial of Endovenous Laser Ablation Versus Conventional Surgery for Small Saphenous Varicose Veins.Nandhra S, El-Sheika J, Carradice D, Wallace T, Souroullas P, Samuel N et al.
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• A Randomised clinical trial of buffered tumescent local anesthesia during endothermal ablation for superficial venous incompetence.Nandrah S, Wallace T, El-Sheika J, Leung C, Carradice D, Chthesia during tter I.
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• A randomised controlled trial ofperivenous tumescent anaesthesiain addition to general anaesthesiafor surgical ligation and strippingof the great saphenous veinNandrah S, Wallace T, El-Sheika J, Carradice D, Chetter I
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• Early results from a randomized trial of saphenous surgery with or without subfascial endoscopic perforator surgery in patients with a venous ulcerNelzén O, Fransson I
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• Local anaesthesic flush reduces post-operative pain and haematoma formation after great saphenous vein stripping : a randomised controlled trial.Nisar A, Shabbir J, Tubassam P et al.
Eur J Vasc Endovasc Surg. 2006;31:325-331.
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• A prospective Double-Blind Randomized Controlled Trial of Radiofrequency Versus Laser Treatment of the Great Saphenous Vein in Patients With Varicose Veins.Nordon IM, Hinchliffe RJ, Brar R, Moxey P, Black SA, Thompson MM, Loftus IM.
Annals of Surgery. 2011;254(6):876-881.
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• A Randomised Controlled Trial Comparing Three Different Radiofrequency Technologies: Short-Term Results of the 3-RF Trial.Nyamekye IK, Dattani N, Hayes W, Harding D, Holloway S, Newman J
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• Randomised clinical trial of foam sclerotherapy for patients with a venous leg ulcer.O'Hare JL, Earnshaw JJ.
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• Role of Compression After Radiofrequency Ablation ofVaricose Veins: A Randomised Controlled TrialOnwudike M, Abbas K, Thompson P, McElvenny DM
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• Efficacy of polidocanol foam versus liquid in sclerotherapy of the great saphenous vein: a multicentre randomised controlled trial with a 2 year follow-up.Ouvry P, Allaert FA, Desnos P, Hamel-Desnos C.
Eur J Vasc Endovasc Surg. 2008;36:366-370.
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• Randomized Clinical Trial of Different Bandage Regimens after Foam Sclerotherapy for Varicose Veins.O’Hare JL, Stephens J, Parkin D, et al.
Br J Surg. 2010;97:650-656.
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• 1470 nm diode laser for endovenous ablation (EVLA) of incompetent saphenous veins – a prospective randomized pilot study comparing warm and cold tumescence anesthesia.Pannier F, Rabe E, Maurins U.
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• Varicose vein surgery. Stripping versus the CHIVA method: a randomized controlled trial. Parés JO, Juan J, Tellez R, Mata A, Moreno C, Quer FX et al.
Ann Surg. 2010; 251:624-631.
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• Treatment of lower extremity telangiectasias in women by foam sclerotherapy vs. Nd:YAG laser: a prospective, comparative, randomized, open-label trial.Parlar B, Blazek C, Cazzaniga S, Naldi L, Kloetgen HW, Borradori L, Buettiker U.
J Eur Acad Dermatol Venereol. 2015 Mar;29(3):549-54
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• Radiofrequency endovenous obliteration versus stripping of the long saphenous vein in the management of primary varicose veins: 3-year outcome of a randomized study.Perala J, Rautio T, Biancari F, Ohtonen P, Wiik H, Heikkinen T, Juvonen T.
Ann Vasc Surg. 2005;19:669-672.
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• Treatment of Reticular and Telangiectatic Leg Veins:Double-Blind, Prospective Comparative Trial ofPolidocanol and Hypertonic SalinePeterson JD, Goldman MP, Weiss RA, Duffy DM, Fabi SG, Weiss MA, Guiha I
Dermatol Surg. 2012 Aug;38(8):1322-30
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• Endoscopic versus open subfascial division of incompetent perforating veins in the treatment of venous leg ulceration: a randomized trial.Pierik EGJM, Van Urj H, Hop CJ, Wittens CHA.
J Vasc Surg. 1997;26:1049-1054.
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• Post-procedural Compression vs. No Compression After Radiofrequency Ablation and Concomitant Foam Sclerotherapy of Varicose Veins: ARandomised Controlled Non-inferiority TrialPihlaja T, Romsi P, Ohtonen P, Jounila J, Pokela M
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• Randomised Controlled Trial Comparing Sapheno-Femoral Ligation and Stripping of the Great Saphenous Vein with Endovenous Laser Ablation (980 nm) Using Local Tumescent Anaesthesia: One Year Results.Pronk P, Gauw SA, Mooij MC,Gaastra MTW, Lawson JA, van Goethem AR, van Vlijmen-van Keulen CJ.
Eur J Vasc Endovasc Surg. 2010;40:649-656.
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• Efficacy and safety of great saphenous vein sclerotherapy using standardised polidocanol foam (ESAF): a randomised controlled multicentre clinical trial.Rabe E, Otto J, Schliephake D, Pannier F.
Eur J Vasc Endovasc Surg. 2008:35:238-245.
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• Sclerotherapy of telangiectases and reticular veins:a double-blind, randomized, comparative clinicaltrial of polidocanol, sodium tetradecyl sulphateand isotonic saline (EASI study)Rabe E, Schliephake D, Otto J, Breu FX, Pannier F
Phlebology. 2010 Jun;25(3):124-31.
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• Double-blind prospective comparative trial between foamed and liquid polidocanol and sodium tetradecyl sulfate in the treatment of varicose and telangiectatic leg veins.Rao J, Wildemore JK, Goldman MP.
Dermatol Surg. 2005 Jun;31(6):631-5; discussion 635.
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• There is no benefit from 6 weeks’ postoperative compression after varicose vein surgery: a prospective randomised trial.Raraty M G T, Greaney M G, Blair S D.
Phlebology. 1999; 14:21-25. doi: 10.1177/026835559901400106
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• A randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins.Rasmussen LA, Lawaetz M, Bjoern L, Vennits B, Blemings A, Eklof B.
Br J Surg. 2011;98:1079-1087
Table XV | Article in PubMed

• Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins with 3 year follow-up.Rasmussen LA, Lawaetz M, Serup J, Bjoern L, Vennits B, Blemings A, Eklof B.
J Vasc Surg & Venous Lym Dis 2013;1:349-356
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• Randomized trial comparing endovenous laser ablation of the great saphenous vein with ligation and stripping in patients with varicose veins : short-term results.Rasmussen LH, Bjoern L, Lawaetz M, Blemings A, Lawaetz B, Eklof B.
J Vasc Surg. 2007;46:308-315.
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• Randomized trial comparing endovenous laser ablation with stripping of the great saphenous vein: clinical outcome and recurrence after 2 years.Rasmussen LH, Bjoern L, Lawaetz M, Blemings A, Lawaetz B, Eklof B.
Eur J Vasc Endovasc Surg. 2010;39:630-635.
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• Randomized trial comparing endovenous laser ablation and stripping of the great saphenous vein with clinical and duplex outcome after 5-years.Rasmussen LH, Lawaetz M, Bjoern L, Blemings A, Eklof B.
J Vasc Surg. 2013;56:421-426.
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• Comparable effectiveness of endovenous laser ablation and high ligation with stripping of the great saphenous vein: two-year results of a randomized clinical trial (RELACS study).Rass K, Frings N, Glowack P, Hamsch C, Gräber S, Vogt T, Tilgen W.
Arch Dermatol.2012;148;49-58.
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• Same Site Recurrence is More Frequent After Endovenous Laser Ablation Compared with High Ligation and Stripping of the Great Saphenous Vein: 5 year Results of a Randomized Clinical Trial (RELACS Study).Rass K, Frings N, Glowacki P, Gräber S, Tilgen W, Vogt T.
Eur J Vasc Endovasc Surg. 2015;50(5):648-656.
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• Cost effectiveness analysis of surgery versus conservative treatment for uncomplicated varicose veins in a randomized control trial.Ratcliffe J, Brazier JE, Campbell WB, Palfreyman SJ, MacIntyre JB, Michaels JA.
Br J Surg. 2006;93:182-186.
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• Endovenous obliteration versus conventional stripping operating in the treatment of primary varicose veins: a randomized controlled trial with comparison of the costs.Rautio T, Ohinmaa A, Perala J, Ohtonen P, Heikkiken T, Wiik H et al.
J Vasc Surg. 2002;35:958-965.
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• A randomised controlled trial of neuromuscular stimulation in non-operative venous disease improves clinical and symptomatic statusRavikumar R, Lane TRA, Babber A, Onida S, Davies AH
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• A randomized controlled trial comparing transilluminated powered phlebectomy with hook avulsions: an adjunct to day surgery.Ray-Chaudury SB, Huq Z, Souter RG, McWhinnie D.
The Journal of One Day Surgery. 2003;13:24-27.
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• Efficacy and comfort of medicalcompression stockings with lowand moderate pressure six weeksafter vein surgeryReich-Schupke S, Feldhaus F, Altmeyer P, Mumme A, Stücker M
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• Advantages and disadvantages ofgraduated and inverse graduatedcompression hosiery in patients withchronic venous insufficiency and healthyvolunteers: A prospective, mono-centric,blinded, open randomised, controlledand cross-over trialRiebe H, Konschake W, Haase H, Jünger M
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• For how long do we have to advise elastic support after varicose vein surgery? A prospective randomized study.Rodrigus I, Bleyn J.
Phlebology. 1991;6:95-98. doi: 10.1177/026835559100600207
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• Endovenous laser ablation versus conventional surgery in the treatment of small saphenous vein incompetence.Roopram AD, Lind MY, Van Brussel JP, Terloux-Punt LC, Birnie E, De Smet AEA et al.
J Vasc Surg: Venous and Lym Dis. 2013;1 357-363.
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• Randomized double-blinded study comparing medical treatment versus iliac vein stenting in chronic venous disease.Rossi FH, Kambara AM, Izukawa NM, Rodrigues TO, Rossi CB, Sousa AG, Metzger PB, Thorpe PE.
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• Randomized trial of stripping versus high ligation combined with sclerotherapy in the treatment of the incompetent greater saphenous vein.Rutgers PH, Kitslaar PJEHM.
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• Randomized Clinical Trial of Endovenous Laser Ablation Versus Conventional Surgery for Small Saphenous Varicose Veins.Samuel N, Carradice D, Wallace T, Mekako A, Hatfield J, Chetter I.
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• Comparison of 12-W versus 14-W Endovenous laser ablation in the treatment of great saphenous varicose veins: 5-Year outcomes from a randomized controlled trial.Samuel N, Wallace T, Carradice D, Mazari F AK, Chetter C.
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• Stripping of the great saphenous vein under micronized purified flavonoid fraction (MPFF) protection (results of the Russian multicenter controlled trial DEFANCESaveljev VS, Pokrovsky AV, Kirienko AI, YU. Bogachev V, Zolotukhin IA, SapelkinSV
Phlebolymphology. 2008;15(2):45-51.
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• Hook phlebectomy versus transilluminated powered phlebectomy for varicose veins surgery. Early results. Scavée V, Lesceu O, Theys S et al.
Eur J Vasc Endovasc Surg. 2003;25: 473-475.
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• Conventional versusinvaginated stripping of the great saphenous vein : a randomized double–controlled clinical trial.Scheltinga MR, Wijburg ER, Keulers BJ, De Kroon CE.
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• Compression versus sclerotherapy for patients withisolated refluxing reticular veins and telangiectasia:a randomized trial comparing quality-of-lifeoutcomesSchul MW, Eaton T, Erdman B.
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• Varicoseveins:optimum compression following scierotherapyScurr JH, Coleridge-Smith P, Cutting P
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• Randomized clinical trial of ultrasoundguided foam sclerotherapy versus surgery for the incompetent great saphenous vein.Shadid N, Ceulen R, Nelemans P, et al.
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• Randomized clinical trial of VNUS Closure FASTTM radiofrequency ablation versus laser for varicose veins.Shepherd AC, Gohel MS, MD,Brown LC, Metcalf MJ, Hamish M, Davies AH.
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• Cost-effectiveness of radiofrequency ablation versus laser for varicose veins.Shepherd AC, Ortega-Ortega M, Gohel MS, Epstein D, Brown LC, Davies AH
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• Prospective randomized trial comparing radiofrequency ablation and complete saphenous vein stripping in patients with mild to moderate chronic venous disease with a 3-year follow-upSincos IR, Baptista APW, Coelho Neto F, Labropoulos N4 Alledi LB, Marins EM, Puggina J, Belczak SQ, Cardoso MG, Aun R
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• Randomised trial of preoperative colour duplex marking in primary varicose vein surgery: Outcome is not improved.Smith JJ, Brown L, Greenhalgh RM, Davies AH.
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• Effect of pharmacotherapy on course of postoperative period after endovenous thermal ablationStoiko YM, Mazaishvili KV, Khlevtova TV, Tsyplyashchuk AV, Kharitonova SE, Akimov SS.
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• Comparative outcomes of radiofrequency endoluminal ablation, invagination stripping and cryostripping in the treatment of great saphenous vein insufficiency.Stötter L, Schaaf I, Bockelbrink A.
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• Radiofrequency ablation vs conventional surgery for varicose veins-a compison of treatment costs in a randomized trial.Subromania S, Lees T.
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• Endoscopic versus open subfascial division of incompetent perforating veins in the treatment of venous leg ulceration: Long-term follow-up.Sybrandy JEM, van Gent WB, Pierik EGJM, Wittens CHA.
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• A randomized prospective long-term (>1 year) clinical trial comparing the efficacy and safety of radiofrequency ablation to 980 nm laser ablation of the great saphenous vein.Sydnor M, Mavropoulos J, Slobodnik N, Wolfe L, Strife B, Komorowski D.
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• A prospective randomised trial of tourniquet in varicose vein surgery.Sykes TC, Brookes P, Hickey NC.
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• Cost- effectiveness of ultrasound- guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial.Tassie E, Scotland G,Brittenden J, Cotton SC, Cambell MK, Gough M et al.
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• Laser ablation versus mechanochemical ablation in thetreatment of primary varicose veins: A randomizedclinical trialTawfik AM, Sorour WA, El-Laboudy ME
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• Endovenous laser ablation: does standard above-knee great saphenous vein ablation provide optimum results in patients with above-and below-knee reflux. A randomized controlled trial. Theivacumar NS, Dellagrammmaticas D, Mavor AID, Gough MJ.
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• Neovascularization and Recurrence 2 years after treatment for sapheno-femoral and great saphenous reflux: a comparison of surgery and endovenous laser.Theivacumar NS, Darwood MJ, Gough MJ.
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• The VANISH-2 study: a randomized, blinded, multicenter study to evaluate the efficacy and safety of polidocanol endovenous microfoam 0,5% and 1,0% compared with placebo for the treatment of saphenofemoral junction incompetence.Todd KL, Wright DI; VANISH-2 Investigator Group
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• Reduction of varicose vein recurrence by use of post-operative compression stockings.Travers JP, Makin GS.
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• Postoperative limb compression in reduction of haemorrhage after varicose vein surgeryTravers JP, Rhodes JE, Hardy JG, Makin GS.
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• Comparison of efficacy and safety between foam sclerotherapy and conventional sclerotherapy: a controlled clinical trial.Ukrimanoroat T,
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• Five-year follow-up of a randomized clinical trial comparing open surgery, foam sclerotherapy and endovenous laser ablation for great saphenous varicose veins.Vähäaho S, Halmeski K, Albäck A, Saarinen F, Venermo M
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• Randomized clinical trial of mechanochemical and endovenous thermal ablation of great saphenous varicose veinsVähäaho S, Mahmoud O, Halmesmäki K, Albäck A, Noronen K, Vikatmaa P, Aho P, Venermo M
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• Randomized clinical trial of endovenous laser ablation versus steam ablation(LAST trial) for great saphenous varicose veins.van der Bos R R, Malskat W S J, De Maeseneer M G R, de Roos K P, Groeneweg D A G, Kockaert M A, Neumann H A M, Nijsten T.
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• Five-year results of a randomized clinical trial of conventional surgery, endovenous laser ablation and ultrasound-guided foam sclerotherapy in patients with great saphenous varicose veins.van der Velden SK, Biemans AA, De Maeseneer MG, Kockaert MA, Cuypers PW, Hollestein LM, Neumann HA, Nijsten T, van den Bos RR.
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• Conservative versus surgical treatment of venous leg ulcers : A prospective, randomized, multicenter trial.van Gent WB, Hop WC, Van Prag MC, Mackaay AJ, de Boer EM, Wittens CH.
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• Influence of perforating vein surgery in patients with venous ulceration.van Gent WB, Wittens CHA.
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• Mechanical Inhibition of Angiogenesis at the Saphenofemoral Junction in the Surgical Treatment of Varicose Veins. Early Results of a Blinded Randomized Controlled Trial. van Rij AM, Jones GT, Hill, G, Amer M, Thomson IA, Pettigrew RA, Packer SGK.
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• Role of subfascial endoscopic perforator surgery (SEPS) in management of perforator in competence in varicose veins : a prospective randomized study.Vashist MG, Malik V, Singhal N.
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• A multicenter, randomized, placebo-controlled trial of endovenous thermal ablation with or without polidocanol endovenous microfoam treatment in patients with great saphenous vein incompetence and visible varicosities.Vasquez M, Gasparis AP; Varithena® 017 Investigator Group.
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• Randomized clinical trial comparing surgery, endovenous laser ablation and ultrasound-guided foam sclerotherapy for the treatment of great saphenous varicose veins.Venermo M, Saarinen J, Eskelinen E, Vähäaho S, Saarinen E, Railo M, Uurto I, Salenius J, Albäck A; Finnish Venous Study Collaborators.
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• Analysis of the various procedures used in great saphenous vein surgery in the Czech Republic and benefit of Daflon 500 mg to postoperative symptomsVeverková L, KALAČ J, JEDLIČKA V, WECHSLER J
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• Endovenous laser treatment for varicose veins in patients with active ulcers: measurement of intravenous and perivenous temperatures during the procedure.Viarengo ML, Potério-Filhio J, Potério M Menezes FH, Meirelles GV.
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• Endovenous laser obliteration for the treatment of primary varicose veins.Vuylstecke M, Van den Busche D, Audenaert EA, Lissens P.
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• Endovenous laser treatment: is there a clinical difference between using a1500 nm and a 980 nm diode lmasert ? A multicenter randomised clinical trial.Vuylsteke M, De Bo H,Dompe G, Di Crisci D, Abbad, CM, Mordon S.
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• Endovenous laser ablation of the great saphenous vein using a bare fibre versus a tulip fibre : a randomised clinical trial.Vuylsteke M, Thomis S, Mahieu P, Mordon S , Fourneau I.
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• Effect of external valvuloplasty of the deep vein in the treatment of chronic venous insufficiency of the lower extremity.Wang S-M, Hu Z-J, Li S-Q, Huang X-L, Ye C-S.
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• Causes of varicose vein recurrence: late results of a randomized controlled trial of stripping the long saphenous vein.Winterborn R.J, Foy C , Earnshaw J.J.
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• Randomized trial of flush saphenofemoral ligation for primary great saphenous varicose veins.Winterborn R.J, Foy C , Heather H, Earnshaw J.J.
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• Assessment of the efficacy and safety of steam vein sclerosis as compared to classic surgery in lower extremity varicose vein management.Wozniak W, Mlosek RK, Ciostek P.
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• Varisolve® polidocanol microfoam compared with surgery or sclerotherapy in the management of varicose veins in the presence of trunk vein incompetence: European randomized controlled trial.Wright D, Gobin J-P, Bradbury AW, Coleridge-Smith P, Spooelstra H et al.
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• Comparative Study of Duplex-Guided Foam Sclerotherapy and Duplex-Guided Liquid Sclerotherapy for the Treatment of Superficial Venous Insufficiency.Yamaki T, Nozaki M, Iwasaki.
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• Prospective randomized efficacy of ultrasound-guided foam sclerotherapy compared withultrasound-guided liquid sclerotherapy in thetreatment of symptomatic venous malformationsYamaki T, Nozaki M, Sakurai H, Takeuchi M, Soejima K, Kono T
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• Prospective Randomised Comparative Study of Visual Foam Sclerotherapy Alone or in Combination with Ultrasound-guided Foam Sclerotherapy for Treatment of Superficial Venous Insufficiency: Preliminary Report.Yamaki T, Hamahata A, Soejima K, Kono T, Nozaki M, Sakurai H.
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• Randomized clinical trial of endovenous microwave ablation combined with high ligation versus conventional surgery for varicose veins.Yang L, Wang XP, Su WJ, Zhang Y, Wang Y.
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• Post-operative Benefit of Compression Therapy after Endovenous Laser Ablation for Uncomplicated Varicose Veins: A Randomised Clinical Trial.Ye K, Wang R, Qin J, Yang X, Yin M, Liu X, Jiang M, Lu X.
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• Prospective Randomized Study of Ultrasound-Guided Foam Sclerotherapy Combined with Great Saphenous Vein High Ligation in the Treatment of Severe Lower Extremity Varicosis.Yin H, He H, Wang M, Li Z, Hu Z, Yao C, Wang J, Wang S, Chang G.
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• [A random, comparative study on endovenous laser therapy and saphenous veins stripping for the treatment of great saphenous vein incompetence.]Ying L, Sheng Y, Ling H, Lian Y, Hui Y, Ming W.
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• Hemodynamic CHIVA correction surgery versus compression for primary venous ulcers: first year results.Zamboni P, Cisno C, Marchetti P, Fogato L, Carandina S, De Palma M et Liboni A.
Phlebology. 2004;19:28-34. doi:10.1258/026835504773042248
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• Minimally invasive surgical management of primary venous ulcers vs. compression treatment: a randomized clinical trial. Zamboni P, Cisno C, Marchetti F, Mazza L, Fogato L, Carandina S, De Palma M, Liboni A.
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